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在Polyvinylpyrrolidone中对水的X射线衍射

C J Benmore¹, S R Benmore², S K Wilke^1,2

¹X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439, USA.

Molecular pharmaceutics

|June 12, 2023

概括

使用X射线散射研究了聚烯 (PVP) 的水吸附. 水分子更喜欢相互结合而不是PVP,在较高度下形成孤立的集群.

科学领域:

聚合物科学聚合物科学
材料科学是一种材料科学.
物理化学物理化学

背景情况:

聚烯 (PVP) 是一种性聚合物,广泛用于制药配方中作为辅助剂.
了解水-PVP相互作用对于预测药物稳定性和释放特征至关重要.

研究的目的:

在不同湿度条件下研究PVP中的结构变化和水吸附动态.
使用先进的散射技术和计算建模量化水-水和水-PVP相互作用.

主要方法:

时间解析的高能X射线散射实验在不同湿度水平的PVP颗粒上进行.
对控制含水量 (2-12.3重量% H2O) 的PVP粉末进行散射测量.
实证潜在结构精细化 (EPSR) 建模用于分析结构数据.

主要成果:

观察到水吸收的两相指数衰减.
在微分对分布函数中2.85 Å的峰值表明碳氧-水氧-结合.
EPSR模型显示了协调数和水含量之间的线性关系,优先考虑的是水-水结合.

结论:

随着含水量的增加,PVP结构不断演变.
水分子表现出一种更强的偏好,与PVP碳基团相比,它们更喜欢相互结.
在大约12重量%的H2O中,每个水分子平均与另一个水分子结合.

关键词:

在 EPSR 建模中.科利登 (Kollidon) 是一个古老的小镇.在X射线中,X射线的衍射效果是不同的.无形结构是无形的结构.配对分配函数的配对分布函数聚维尼尔皮罗利多的使用.

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