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限制白的饮食改善了与肥胖有关的认知缺陷:微生物群-肠-大脑轴的参与

Danna Wang¹, Luyao Wang¹, Liuyang Han¹

¹Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China.

Journal of agricultural and food chemistry

|June 12, 2023

概括

氨酸限制 (LR) 通过改善肠道微生物群平衡和增加有益的短链脂肪酸 (SCFA) 来对抗肥胖症的认知衰退. 这种饮食方法可以增强大脑健康,并可以逆转饮食引起的记忆障碍.

科学领域:

神经科学是一个神经科学.
代谢过程中的代谢.
微生物学微生物学

背景情况:

已知氨酸限制 (LR) 可以改善胰岛素耐药性,并促进脂肪组织的色.
LR对与肥胖相关的认知障碍的影响尚不清楚.

研究的目的:

为了研究8周的白素限制 (LR) 对高脂肪饮食 (HFD) 诱导的认知衰退的影响.
探索潜在的机制,包括突触功能的变化,神经营养因子,神经炎症和肠道微生物群.

主要方法:

给小鼠食高脂肪饮食 (HFD) 持续8周,其中一组接受了白素限制 (LR).
评估了认知功能,并分析了大脑组织的突触标记物,神经营养因子和炎症标记物.
用测序分析了肠道微生物组成,并测量了肠道屏障完整性标记物.

主要成果:

在HFD养的小鼠中,LR显著改善了认知功能,预防了突触功能障碍,并减少了与记忆相关的大脑区域的神经炎症.
LR增加了神经变因子的表达和积极调节的肠道微生物群组成,降低了Firmicutes/Bacteroidetes的比率.
LR恢复了短链脂肪酸 (SCFA) 的水平,改善了肠道屏障功能,并减少了脂多糖 (LPS) 泄漏.

结论:

氨酸限制 (LR) 是减轻肥胖引起的认知缺陷的有效策略.
通过恢复肠道微生物群的稳态和增强SCFA生产,LR的好处可能会得到调解.
LR提供了一种潜在的饮食干预,用于管理与肥胖和代谢功能障碍相关的认知障碍.

关键词:

在SCFAs中,SCFAs是最重要的.认知功能认知功能肠-大脑轴肠-大脑轴这是一种炎症炎症炎症炎症.素的限制限制.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖

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