基于的Sm/Co-Doped纳米酶重新编程瘤微环境以进行ATP抑制的瘤治疗
Siyi Li1, He Ding1, Jinghu Chang1
1Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China.
Advanced healthcare materials
|June 12, 2023
概括
这项研究引入了新的纳米酶,通过抑制能量产生和增强反应性氧物种 (ROS) 生成来重编程瘤微环境 (TME),在瘤细胞亡的光热治疗的帮助下.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 目前的纳米酶在瘤微环境 (TME) 内的催化活性和稳定性方面面临挑战.
- 重新编程TME氧化还原平衡对于有效的癌症治疗至关重要.
研究的目的:
- 开发用于同时进行TME重编程和瘤细胞亡诱导的多功能纳米酶.
- 通过增强的催化活性和稳定性,克服现有纳米酶的局限性.
主要方法:
- 用3PO (mSC-3PO) 装载的Sm/Co-doped半孔化纳米酶的构造.
- 利用增强的过氧化酶类,酶类和谷甲过氧化酶类活动.
- 嵌入式光热疗法与近红外 (NIR) 光吸收.
主要成果:
- mSC-3PO在TME条件下表现出高的催化活性和稳定性.
- 实现了同时抑制ATP生产和ROS生成.
- 有效地重编程TME,促进氧含量和抑制谷氨.
结论:
- 开发的mSC-3PO纳米酶为癌症治疗提供了一个有前途的治疗策略.
- 具有光热辅助的多功能纳米酶可以有效诱导瘤细胞亡.
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