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Updated: Jul 26, 2025

Evaluating In Vitro DNA Damage Using Comet Assay
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Published on: October 11, 2017

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泰莫佐洛米德使ARID1A突变癌症对PARP抑制剂产生敏感性

Zheng-Cheng Yu1,2,3, Tianhe Li1,2,3, Ellen Tully1,2,3

  • 1Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland.

Cancer research
|June 12, 2023
PubMed
概括

卵巢癌中的ARID1A突变会影响DNA修复. 将temozolomide与PARP抑制剂相结合利用了这一缺陷,导致合成致死性,并在临床前模型中抑制瘤生长.

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