在复发性/耐药性扩散性大B细胞淋巴瘤中,PD-1阻塞结合ICE疗法
Liqin Ping1, Yan Gao1, Yanxia He1
1Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China.
结合PD-1阻断和ICE化疗的P-ICE疗法,在复发性/耐药性扩散性大B细胞淋巴瘤 (DLBCL) 患者中显示出有希望的疗效和轻度毒性. 这种治疗为预后不佳的患者提供了新的选择.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
背景情况:
- 复发性/耐药性扩散性大B细胞淋巴瘤 (R/R DLBCL) 的预后不好.
- 标准的救援化疗 (ICE) 的疗效有限.
- DLBCL通过PD-L1上调来逃避免疫监测.
研究的目的:
- 评估PD-1阻断与ICE (P-ICE) 结合用于R/R DLBCL的疗效和安全性.
- 探索P-ICE治疗反应的预后生物标志物.
主要方法:
- 对67名用P-ICE治疗的R/R DLBCL患者的回顾性分析.
- 随访时间中位数为24.7个月.
- 临床特征和分子标记物的分析.
主要成果:
- 目标响应率 (ORR) 为62.7%,完整响应率 (CRR) 为43.3%.
- 两年无进展生存率 (PFS) 为41.1%,总生存率 (OS) 为65.6%.
- 年龄,阶段,IPI得分和先前的反应预测了ORR. 血小板缺血是最常见的3/4级AE (9.0%).
结论:
- P-ICE疗法在R/R DLBCL中显示出有希望的疗效.
- P-ICE表现出可控的毒性,没有与治疗相关的死亡.
- 这种组合疗法代表了R/R DLBCL的可行的治疗选择.
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