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药物和纳米粒子加工中的可持续性
1Division of Pharmaceutical Technology and Biopharmacy, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. dagmar.fischer@fau.de.
Handbook of experimental pharmacology
|June 12, 2023
概括
绿色溶剂提供了一种可持续的替代方案,用于制造聚乳糖合糖酸 (PLGA) 纳米粒子,解决与传统有机溶剂相关的环境和健康问题.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 绿色化学 绿色化学
背景情况:
- 聚乳糖糖酸 (PLGA) 纳米颗粒对于药物输送至关重要,通过纳米沉和纳米乳液等方法制造.
- 在PLGA纳米粒子配方中使用的传统有机溶剂对环境和健康构成风险.
- 在纳米粒子制造中,对可持续和绿色替代品的需求越来越大.
研究的目的:
- 审查用于PLGA纳米粒子配方的传统和替代溶剂.
- 评估溶剂特性对配方过程和颗粒特性的影响.
- 介绍和比较PLGA纳米粒子合成的新型绿色溶剂.
主要方法:
- 经典纳米配方中的辅助剂和有机溶剂的概述.
- 分析绿色,可持续和替代溶剂,包括它们的特性和局限性.
- 介绍和比较用于PLGA纳米粒子形成的新型替代溶剂.
- 在纳米纤维素矩阵内的现场粒子形成的评估.
主要成果:
- 溶剂的物理化学性质 (可溶性,粘度,蒸气压) 显著影响配方和粒子特性.
- 新的替代溶剂显示了PLGA纳米粒子形成的潜力.
- 对新型溶剂的粒子特性和生物效应进行比较分析.
- 在使用替代溶剂的纳米纤维素基质中成功地在现场形成PLGA纳米粒子.
结论:
- 新型绿色溶剂在PLGA纳米粒子配方中取代危险的有机溶剂方面取得了重大进展.
- 这些替代品为纳米粒子制造提供了更好的可持续性和安全性.
- 这些发现为更绿色的药物输送系统铺平了道路.
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