富含库尔库明的咖的消费和预期寿命:新加坡纵向衰老研究
Tze Pin Ng1,2, Shwe Zin Nyunt3, Qi Gao4
1Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Level 9, NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore. pcmngtp@nus.edu.sg.
GeroScience
|June 12, 2023
概括
咖消费中的食黄素显示出潜在的健康益处. 适度摄入与降低死亡率和增加预期寿命有关,特别是在有心脏代谢疾病的人群中.
科学领域:
- 老年学是一门学科.
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
背景情况:
- 黄中的一种化合物黄,正在研究其治疗潜力.
- 有限的现实世界数据存在于咖的饮食黄素的咖消费及其对健康和寿命的影响.
- 这项研究通过检查老年人咖的咖消费来弥补这一差距.
研究的目的:
- 研究饮食咖食量与健康结果 (包括死亡率和预期寿命) 之间的关联.
- 探索咖摄入量与各种健康生物标志物和疾病患病率之间的关系.
- 为了确定适度咖的消费是否会给长寿带来好处.
主要方法:
- 这是一项针对4551名55岁以上的成年人进行的前性队列研究.
- 评估咖的消费频率,普遍的健康状况,以及基线血液生物标志物.
- 追踪参与者平均11.6年来追踪所有原因,心血管和癌症死亡率.
主要成果:
- 增加咖的消费显示了与不良代谢标记 (例如腰围,禁食葡萄糖) 的线性关联,但与EGFR的反向关联.
- 观察到呼吸功能,认知功能和并发症的非线性关联,适度消费是最有利的.
- 咖的消费线性降低了全身炎症标志物 (NLR,PLR,SII). 适度摄入与显著降低死亡风险和增加预期寿命有关,特别是在患有心脏代谢疾病的人群中.
结论:
- 适度的咖消费可能会带来显著的长寿益处.
- 咖摄入的食库尔库与改善的健康标志物和降低死亡风险有关.
- 需要进一步研究这些观察到的健康益处背后的机制.
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