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相关概念视频

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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相关实验视频

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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

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瘤解毒病毒疗法病毒疗法

Munazza Fatima1, Deeba Amraiz2, Muhammad Tariq Navid1

  • 1Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan.

Cancer treatment and research
|June 12, 2023
PubMed
概括

瘤病毒 (OVs) 通过选择性地破坏癌细胞,提供了有前途的癌症治疗方法. 这种免疫疗法方法正在进步,OV在临床试验中作为单一疗法或与传统治疗相结合,取得了成功.

科学领域:

  • 在瘤学瘤学.
  • 病毒学 病毒学
  • 免疫治疗是一种免疫疗法.

背景情况:

  • 传统的癌症疗法有其局限性.
  • 瘤病毒 (OV) 正在成为一个有前途的免疫疗法平台.
  • OVs通过溶解或免疫反应诱导选择性地向和破坏癌细胞.

研究的目的:

  • 描述瘤病毒的基本特征和作用机制.
  • 为不同癌症提供涉及各种瘤病毒的临床试验概述.

主要方法:

  • 对型病毒特征和机制的审查.
  • 从正在进行和已完成的临床试验中收集和分析数据.
  • 探索提高OV功效的策略.

主要成果:

  • 瘤溶解性病毒疗法利用自然存在的或转基因病毒.
  • 几种OV已经在临床试验中证明了对各种癌症的成功.
  • OVs作为单一疗法和与化疗,放射疗法或免疫疗法相结合是有效的.

结论:

  • 瘤性病毒疗法为癌症治疗提供了一种新的方法.
关键词:
癌症治疗治疗 癌症治疗临床试验中的临床试验.免疫治疗是一种免疫疗法.瘤学病毒 瘤学病毒

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  • 进一步了解瘤免疫反应将使OVs能够精确治疗癌症.
  • 瘤病毒有望成为多模式癌症治疗策略的关键组成部分.