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自主神经活动特征根据干眼类型
Minako Kaido1,2, Reiko Arita2,3, Yasue Mitsukura4
1Wada Eye Clinic, Chiba, Japan.
Investigative ophthalmology & visual science
|June 12, 2023
概括
干眼症状与短眼断时间干眼 (sBUTDE) 中的副交感神经活动有关. 在水性眼缺乏干眼 (ADDE) 中,自主神经系统的参与似乎很小.
科学领域:
- 眼科医生 眼科 眼科
- 自主神经科学 自主神经科学
- 医学生理学 医学生理学
背景情况:
- 眼睛干燥 (DE) 是一种普遍存在的眼部疾病,具有不同的病因.
- 了解自主神经系统 (ANS) 在DE症状中的作用对于有针对性的治疗至关重要.
- 区分不同的DE亚型,例如短撕裂时间DE (sBUTDE) 和水性撕裂缺少DE (ADDE),对于阐明潜在的病理生理机制至关重要.
研究的目的:
- 研究不同类型干眼患者的自主神经活动和症状强度之间的关联.
- 确定副交感和交感神经活动以及它们的波动是否与干眼症状严重程度相关.
主要方法:
- 一项前性,横截面研究,涉及25名sBUTDE患者和24名ADDE患者.
- 使用心率变化 (HRV) 参数评估自主神经活动,包括低频 (LF) 和高频 (HF) 组件及其变化 (cvRR,ccvLF,ccvHF).
- 使用日本版本的眼部表面疾病指数 (J-OSDI) 和压力调查问卷来评估症状强度和压力水平.
主要成果:
- 在sBUTDE中,较高的J-OSDI得分与增加的副交感活动 (HF) 和其波动 (ccvHF),以及更高的主观压力显著相关.
- 在ADDE组中,没有发现J-OSDI得分与自主参数或压力之间的显著相关性.
- 这些发现表明,ANS在不同干眼子类型的症状体验中存在差异性参与.
结论:
- 在sBUTDE中,干眼症状与偏交神经活动的幅度和波动有显著的关联.
- 副交感活动在症状的发展中起作用,特别是在sBUTDE.
- 在ADDE中,自主神经系统参与症状产生似乎是最小的,这表明每个亚型的潜在机制不同.
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