童年不良经历与中年加速表观遗传衰老的关联
Kyeezu Kim1, Kristine Yaffe2, David H Rehkopf3
1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
JAMA network open
|June 12, 2023
概括
童年不良经历 (ACE) 与中年成年人的表观遗传衰老加速 (EAA) 有关. 这表明一种分子机制将早期生活中的逆境与生物衰老联系起来,为健康促进策略提供信息.
科学领域:
- 表观遗传学和分子生物学
- 公共卫生和流行病学
- 生命周期发展 寿命发展
背景情况:
- 儿童不良经历 (ACE) 与长期的健康风险有关.
- 识别这些关联背后的分子机制对于促进健康至关重要.
- 表观遗传衰老加速 (EAA) 是一种与健康结果相关的生物标志物.
研究的目的:
- 在人口统计学上平衡的队列中研究ACE和EAA之间的关联.
- 探索EAA作为一个潜在的分子调解者,将童年逆境与中年健康联系起来.
主要方法:
- 使用来自"年轻成人冠状动脉风险发展研究" (CARDIA) 数据的队列研究.
- 在随访15年和20年收集的DNA甲基化数据.
- 评估了五个EAA措施 (IEAA,EEAA,PhenoAA,GrimAA,DunedinPACE) 的情况.
- 线性回归和通用估计方程用于分析ACE负担和EAA之间的关联.
主要成果:
- 较高的ACE负担 (≥4) 与15年和20年EAA积极相关.
- 在15年观察到EEAA,PhenoAA,GrimAA和DunedinPACE的特定关联,并在20年观察到IEAA,EEAA,PhenoAA,GrimAA和DunedinPACE的特定关联.
- 这些关联在调整人口统计,健康行为和社会经济地位后仍然很重要.
结论:
- ACEs与中年成年人的表观遗传衰老加速有关.
- 这项研究突出了潜在的分子途径,将生命早期的逆境与生物衰老联系起来.
- 这些发现支持针对有ACE病史的个体进行健康促进干预的生命过程视角.
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