在白血和半面患者的肉毒毒素治疗后,闪参数不会正常化
Gustavo R Gameiro1, Midori H Osaki, Cristina Yabumoto
1Department of Ophthalmology and Visual Sciences (GRG, MHO, CY, TO, RB, THO), Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil; and Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery (DG, AAVC), University of São Paulo/Ribeirão Preto, R.Preto, Brazil.
概括
毒素 (BoNT) 注射显著降低了眼幅度,频率和速度在白发作 (BSP) 和半面 (HFS) 患者. 然而,与健康对照相比,这些闪参数在治疗后并没有完全正常化.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 在注射肉毒素 (BoNT) 治疗白发 (BSP) 和半面 (HFS) 后闪参数的变化尚不清楚.
- 调查这些客观变化对于了解治疗疗效和患者结果至关重要.
研究的目的:
- 客观地评估毒素 (BoNT) 注射对BSP和HFS患者眼参数的影响.
- 将治疗后眼指标与健康个体的指标进行比较.
主要方法:
- 三十七名BSP和HFS患者在接受abotulinumtoxinA注射之前和30天后进行了评估.
- 使用高速摄像头和微型发光二极管来记录闪频率,振幅和眼关闭速度.
- 数据比较了治疗前和治疗后的状态以及12个年龄匹配的对照组.
主要成果:
- 与基线相比,BoNT注射显著降低了BSP和HFS患者的闪幅度,频率和速度.
- 在治疗后,闪幅度和速度与对照组相比,在BSP和受影响的HFS侧面仍然明显较低.
- 即使在治疗前,BSP和HFS患者的眼关闭速度也明显低于对照组.
结论:
- 虽然眼频率接近正常水平,但在BSP和HFS患者的BoNT治疗后,振幅和速度没有正常化.
- 闪参数,特别是速度,在治疗后仍然有所改变,这表明正常化不完全.
- 减少眼关闭速度是BSP和HFS的内在特征,甚至在BoNT干预之前也存在.
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