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相关概念视频

DNA Microarrays02:34

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Combinatorial Gene Control02:33

Combinatorial Gene Control

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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相关实验视频

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Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress
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基于迪科登的测量方法用于基因表达模型.

Andres M Alonso1,2, Luis Diambra2,3

  • 1Instituto Tecnológico Chascomús (INTECH), CONICET-UNSAM, Intendente Marino km 8.2, Chascomús, 7130 Provincia de Buenos Aires, Argentina.

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概括
此摘要是机器生成的。

代对使用显著影响基因表达比单独的代使用偏差. 新的分析显示,二子模式为翻译效率和调节提供了新的见解.

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科学领域:

  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 的使用偏差影响翻译效率,蛋白质折叠和mRNA衰变.
  • 新出现的证据表明,编码体对的使用也在基因表达调节中起着关键作用.

研究的目的:

  • 为了调查是否可以通过codon使用偏差来解释codon对使用模式.
  • 为了确定代码对的使用是否提供了关于编码翻译效率的新信息.

主要方法:

  • 开发了一个权重策略来量化二鱼的贡献.
  • 实施了基于二鱼的测量方法,并将其与基因表达的相关性与二鱼适应指数 (CAI) 进行了比较.

主要成果:

  • 与CAI相比,基于迪科登的测量显示了与基因表达水平的更高相关性.
  • 具有低适应性值的迪科登与酵母菌中强烈的转化抑制有关.
  • 一些子对表现出较小的二子贡献,而不是由单个子贡献预测.

结论:

  • 代码组对使用提供了超越代码组使用偏差的独特信息,以了解翻译效率.
  • 迪科登分析提供了更准确的基因表达水平预测器.
  • 这些发现提高了我们对翻译调节机制的理解.