概括
完整血清 (CBC) 参数,如中性粒细胞与淋巴细胞的比率 (NLR) 和平均血小板量 (MPV),可以有效地评估疾病活性和风湿性疾病的预后. 这些常规检查提供了一个有价值的,可访问的替代方案,以特殊的诊断条件,如类风湿性关节炎和狼.
科学领域:
- 类风湿病学 类风湿病学
- 血液学 血液学 血液学
- 临床病理学 临床病理学
背景情况:
- 类风湿性疾病是影响连接组织的慢性疾病,可能会损害心脏和脏等重要器官.
- 精确的诊断,预后和风湿性疾病的治疗监测通常依赖于专门的,昂贵的和耗时的实验室测试.
研究的目的:
- 评估随时可用的全血计 (CBC) 参数在评估疾病活性和风湿性疾病预后方面的有用性.
- 审查CBC衍生生物标志物的现有文献,用于包括类风湿性关节炎和全身性红斑狼在内的疾病.
主要方法:
- 使用谷歌学者和PubMed数据库进行了全面的文献搜索.
- 审查了2000年至2021年间发表的文章,以确定有关风湿性疾病中CBC参数的研究.
主要成果:
- 中性粒细胞与淋巴细胞比率 (NLR),一种CBC衍生的生物标志物,在评估类风湿性关节炎 (RA) 疾病活性和治疗反应方面表现出有效性.
- 平均血小板体积 (MPV) 和NLR被确定为预测系统性红斑狼 (SLE) 脏干扰预后的指标.
- 传统的标记物如红细胞沉积率 (ESR) 和C反应蛋白 (CRP) 缺乏足够的特异性来评估疾病活性.
结论:
- 基于CBC的参数,包括红细胞分布宽度 (RDW),MPV,NLR和血小板与淋巴细胞比率 (PLR),作为有价值的炎症生物标志物.
- 这些参数具有预后意义,可以有效监测各种类风湿性疾病中的疾病活性.
- 虽然CBC参数并不完全具体,但它为管理类风湿性疾病提供了一种实用且易于使用的方法.
相关概念视频
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
01:22Bone Marrow Sampling and Transplants
363
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
363
01:23Rheumatic Heart Disease I: Introduction
17
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
17
01:20Rheumatic Heart Disease IV: Nursing Management
23
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
23
01:21Rheumatic Heart Disease III: Medical Management
22
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
22