苏马拉A-J:来自Cleistanthus sumatranus的具有免疫抑制活性的基
Jun-Su Zhou1, Jia-Ying Yao2,3, Yuan Gao1
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
Journal of natural products
|June 12, 2023
概括
从*Cleistanthus sumatranus*中分离出了10种新的线原体,包括新的furopyran线原体. 一些化合物表现出免疫抑制活性,抑制B淋巴细胞增殖.
科学领域:
- 自然产品化学 自然产品化学
- 药理学是指药理学,即药理学是指药理学.
- 药用化学 医学化学
背景情况:
- 菲兰太家族的植物是已知的生物活性化合物的来源.
- 体是一种多样化的自然产品类别,具有各种各样的生物活动.
- 克利斯坦斯 (Cleistanthus sumatranus) 是一种具有新化学发现潜力的植物物种.
研究的目的:
- 从 *Cleistanthus sumatranus* 树枝中分离和鉴定新的联化合物.
- 评估分离化合物的免疫抑制潜力.
主要方法:
- 使用光谱数据分析 (NMR,MS) 进行化学调查.
- 通过X射线晶体学和实验性电子圆形二元化 (ECD) 频谱阐明结构.
- 在体外免疫抑制试验中,使用脂聚糖 (LPS) 诱导的B淋巴细胞增殖.
主要成果:
- 分离了十种未被描述的基素,称为苏马特拉宁A-J.
- 识别了四种前所未有的furopyran联,具有新的异构三环框架.
- 两种罕见的9'-nor-dibenzylbutane lignan 的特征.
- 化合物3和9表现出适度的免疫抑制作用,具有良好的选择性.
结论:
- 对*Cleistanthus sumatranus*进行的化学研究产生了新的干结构.
- 苏马特拉宁A-J代表了已知的联化学多样性的显著增加.
- 化合物3和9显示出作为免疫抑制剂的潜力.
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