[在多化学疗法期间远程监测QT间隔]
Z Z A Fashafsha1, P Sh Chomakhidze1, D F Mesitskaya2
1Word-Class Research Center Institute of Personalized Cardiology, Center "Digital Biodesign and Personalized Healthcare of the Sechenov First Moscow State Medical University, Moscow.
Kardiologiia
|June 12, 2023
概括
远程单通道心电图 (ECG) 监测有效地检测长时间纠正的QT间隔 (QTc) 在接受多化学疗法 (PCT) 的癌症患者. 这种方法有助于在治疗期间识别潜在的心律障碍.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 医疗技术 医疗技术 医学技术
背景情况:
- 接受多化学疗法 (PCT) 的癌症患者有心脏并发症的风险.
- 长时间纠正的QT间隔 (QTc) 是潜在心脏事件的重要指标.
- 早期发现QTc延长对于管理治疗和预防不良结果至关重要.
研究的目的:
- 评估在接受选择性PCT的癌症患者中延长QTc间隔的发生率.
- 评估QTc评估的远程单通道心电图 (ECG) 监测的有效性.
主要方法:
- 招募了49名接受选择性PCT的癌症患者队列.
- 在第一个和第二个PCT课程之间,使用便携式CardioQVARK设备记录了单通道,单导电心电图.
- 分析的重点是QTc间隔的持续时间与基线和确定的值 (>480 msec,>500 msec) 相比.
主要成果:
- 在8.2%的患者中观察到延长的QTc间隔 (>500毫秒).
- 18.3%的患者显示QTc间隔大于480毫秒.
- 12.2%的患者与基线相比表现出QTc延长>60毫秒.
结论:
- 远程单通道心电图监测是检测心律异常的有效工具,包括癌症患者的QTc延长.
- 便携式心电图装置可促进持续或频繁的监测,提高化疗期间患者的安全性.
- 这项技术支持瘤护理中的主动心脏风险管理.
相关概念视频
Pulse rhythm
852
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
852
Holter Monitor: 24-Hour Monitoring
67
Holter monitoring is a continuous electrocardiography (ECG) recording that tracks the heart's electrical activity over an extended period, generally 24 to 48 hours. This noninvasive diagnostic tool detects irregular heart rhythms that may not be captured during a standard ECG performed in a clinical setting.DeviceThe Holter monitor is a portable, small device connected to several electrodes on the patient's chest. These electrodes detect the heart's electrical signals and transmit them to the...
67
Electrocardiogram
2.5K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
2.5K
Dysrhythmias V: Evaluating Dysrhythmias
42
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
42
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
1.1K
Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
1.1K
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
51
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
51


