在尿路透镜检查中对单剂量外科手术期间使用Pregabalin进行随机对照试验
Geoffrey H Rosen1, Paige A Hargis2, Alp Kahveci3
1Division of Urology, Department of Surgery, University of Missouri, Columbia, Missouri.
The Journal of urology
|June 12, 2023
概括
单剂量普雷加巴林在尿路透镜检查后没有减轻疼痛. 这项研究发现,在接受尿路透镜检查的患者中,使用普雷加巴林来治疗术后疼痛没有任何益处.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 尿路透镜通常会导致术后疼痛,导致医疗保健利用率增加和阿片类药物处方增加.
- 术后的 gabapentinoids 显示出在手术后减少疼痛和阿片类药物使用的潜力.
研究的目的:
- 为了评估一次剂量的外科手术前前加巴林在尿路透镜检查后减轻疼痛的安全性和有效性.
- 为了确定是否能降低手术后疼痛和阿片类药物消耗在接受尿路透镜的患者.
主要方法:
- 一个盲目的,安慰剂控制的试验,涉及118名接受尿路透镜检查的患者.
- 患者在手术前一小时接受了300毫克普雷加巴林或安慰剂.
- 使用视觉模拟尺度评估疼痛,并在30天内对认知,满意度和阿片类药物使用进行额外评估.
主要成果:
- 接受普雷加巴林治疗的患者更年轻 (中位数为44岁与57岁).
- 术后疼痛得分在预加巴林组 (3.7对2.0,P=.004) 中显著更高,即使在调整年龄和手术前疼痛后.
- 两组之间在认知功能或不良事件报告中没有发现显著差异.
结论:
- 与安慰剂相比,单剂量外科手术期间使用的普雷加巴林在尿路透镜后减少术后疼痛方面没有效果.
- 由于缺乏证明的益处,不建议定期使用普雷加巴林作为尿路透镜治疗疼痛的辅助药物.
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