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肝移植中的性别差异

Rachel Hogen¹, Matthew Hunter Witt, Kiran Dhanireddy

¹Tampa General Hospital, Transplant Institute, Abdominal Organ Transplantation, Tampa, Florida, USA.

Current opinion in organ transplantation

|June 12, 2023

概括

妇女在肝移植 (LT) 获得和等待名单死亡率方面面临性别差异. 修改器官分配系统并考虑性别特定的脆弱性评估对于公平至关重要.

科学领域:

肝病学肝病学是一种肝病学.
移植医学移植医学
健康公平卫生公平

背景情况:

在肝移植 (LT) 率和等待名单死亡率方面存在持续的性别差异.
目前的器官分配系统,特别是末期肝病模型 (MELD-Na),可能会使女性处于不利地位,因为它们依赖血清肌和肌肉质量.
女性在脆弱性评估中表现较差,患非酒精性脂肪肝炎 (NASH) 的患病率更高,这是与脆弱性相关的疾病.

结论:

解决LT中的性别差异需要采用多方面的方法.
未来的分配系统应该旨在尽量减少基于性别的偏见.
对性别特异性脆弱性和疾病进展的进一步研究对于实现公平的LT接入至关重要.

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