免疫检查点抑制剂抑制了固体瘤感染患者的C型肝炎病毒复制
Marcel Yibirin1, Khalis Mustafayev1, Jeff Hosry1
1Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
The American journal of gastroenterology
|June 12, 2023
概括
免疫检查点抑制剂 (ICI) 可以抑制型肝炎病毒 (HCV) 复制,可能导致在没有直接作用抗病毒药物 (DAA) 的情况下治愈病毒. 肝病毒复激活是罕见的,并且与ICI副作用的免疫抑制剂有关,这表明ICI对感染肝病毒的患者是安全的.
科学领域:
- 在瘤学瘤学.
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
背景情况:
- 关于免疫检查点抑制剂 (ICI) 对患有慢性型肝炎病毒 (HCV) 感染的患者的影响的数据有限.
- 评估ICI在这个人群中的病毒学影响和安全性对于治疗决策至关重要.
研究的目的:
- 为了研究ICI对HCV病毒病在患有固体瘤的患者的病毒学影响.
- 评估ICI在HCV感染患者中的安全性.
主要方法:
- 一项前性观察性研究招募了52名ICI治疗的固体瘤患者.
- 主要结局包括ICI诱导的HCV病毒性变化 (抑制和重新激活) 和ICI安全性.
主要成果:
- 四名患者 (7.7%) 经历了HCV抑制,其中一名患者在没有DAA的情况下实现了无法检测的病毒性血清.
- 两名患者 (4%) 患有HCV再激活,主要是因ICI相关毒性影响而服用免疫抑制剂时.
- 大多数不良事件是低级的 (1-2); 3-4级事件是与ICI相关的,不是与HCV相关的. 没有发生HCV相关的肝衰竭或死亡.
结论:
- 在不接受DAA的患者中,ICI可以导致HCV抑制和潜在的病毒治愈.
- 肝炎复兴是不常见的,并且与ICI毒性免疫抑制疗法相关.
- ICI在HCV感染患者中具有固体瘤的安全性表现良好,支持其在没有禁忌的情况下使用.
相关概念视频
01:27Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
02:34Inhibition of Cdk Activity
4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
01:27Cytotoxic T Cells-mediated Immune Response
999
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
999
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
202
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
202
01:51Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K