没有感染性内心炎复发,当治疗结束时氧葡萄糖正子发射断层扫描/计算机断层扫描是负面的
Claudine Régis1,2, Michael Thy3,4, Besma Mahida1,5
1Nuclear Medicine Department, Hôpital Bichat-Claude Bernard, AP-HP, 46 rue Henri-Huchard, Paris 75018, France.
治疗结束时 (EOT) 氧葡萄糖正子发射断层扫描/计算机断层扫描 (FDG-PET/CT) 扫描呈阴性结果,预测无手术感染性内心炎 (IE) 没有复发. 阳性EOT FDG-PET/CT表明IE复发的风险较高.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 核医学就是核医学.
背景情况:
- 非手术感染性内心炎 (IE) 的复发可能会对患者的结果产生负面影响.
- 准确评估治疗有效性对于管理IE至关重要,特别是在未经手术的情况下.
研究的目的:
- 调查治疗结束时 (EOT) 氧葡萄糖正子发射断层扫描/计算机断层扫描 (FDG-PET/CT) 发现与非手术IE患者的疾病复发之间的关联.
- 为了确定EOT FDG-PET/CT在原生或假体中复发的预测值,IE.
主要方法:
- 一组62名未经手术治疗的IE患者在开始服用抗生素30至180天后接受了EOT FDG-PET/CT.
- 对FDG-PET/CT扫描进行了定性和定量分析,将其分类为阳性或阴性.
- 收集和分析了临床数据,包括IE诊断和复发事件.
主要成果:
- 在治疗结束时,FDG-PET/CT对29名患者呈阴性,对33名患者呈阳性.
- 阳性扫描的比例从初始扫描到EOT扫描显著下降 (77%至53%,P < 0.0001).
- 所有7例复发 (11%) 都发生在具有EOTFDG-PET/CT扫描结果阳性的患者中; 没有在具有阴性扫描结果的患者中观察到复发 (P = 0.01).
结论:
- 负面的EOT FDG-PET/CT扫描与未经手术的IE中复发风险明显降低.
- 积极的EOT FDG-PET/CT发现可能表明IE复发的可能性更高.
- 需要更大规模的前性研究来证实这些发现.
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