药物中的硫氧化物
Elżbieta Wojaczyńska1, Jacek Wojaczyński2
1Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50 370, Wrocław, Poland.
Current opinion in chemical biology
|June 12, 2023
概括
本综述探讨了硫黄在医学中的应用,包括用于癌症治疗的天然化合物,如硫黄和阿曼,并讨论了二甲基硫黄的争议. 它还涵盖了质子抑制剂和药物重新定位,用于新的治疗方法.
科学领域:
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
- 药物发现 药物发现 药物发现
背景情况:
- 硫氧化物代表了一类重要的化合物,具有多样化的制药应用.
- 天然和合成硫氧化物正在越来越多地探索其治疗潜力.
- 了解它们的特性对于开发新的候选药物至关重要.
研究的目的:
- 提供关于含硫氧化物药物的当前制药市场状况的全面概述.
- 突出天然硫氧化物,如硫和阿曼的治疗潜力.
- 讨论硫氧化物在药物重新定位和性切换策略中的应用.
主要方法:
- 科学文章和专利的文献评论.
- 对硫化物药物的当前制药市场数据的分析.
- 关于特定硫化物化合物及其应用的案例研究.
主要成果:
- 天然硫氧化物,如硫福拉和阿马尼丁,显示出有前途的效果,阿马尼丁用于抗体-药物结合物治疗癌症.
- 讨论了二甲基硫氧化物 (DMSO) 在医学中的使用,包括相关的争议.
- 质子抑制剂 (PPI) 受益于性切换策略,利用纯粹的反体.
- 药物重新定位发现了modafinil和sulindac的新应用.
- 塞尼克里维罗克和阿德兹马皮莫德被认为是有前途的候选药物.
结论:
- 硫氧化物涵盖了广泛的治疗应用,从天然产品到合成药物.
- 基拉尔切换和药物重新定位是优化硫化物治疗的可行策略.
- 新兴的候选药物,如森克里维罗克和阿德兹马皮莫德,突显了硫氧化物在药物开发中的持续重要性.
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