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肺功能指数不会影响患有睡眠呼吸障碍的患者冠心病的发病率

Heze Fan¹, Ying Xiong¹, Yuzhi Huang¹

¹Cardiovascular Department, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710061, China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, 710061, China.

|June 12, 2023

概括

肺功能预测冠心病 (CHD) 风险,特别是在没有睡眠呼吸障碍 (SDB) 的个人中. 肺功能下降与非SDB患者的CHD发病率较高有关,但不是SDB患者.

科学领域:

心脏病学心脏病学
肺部病理学肺部病理学
睡眠医学睡眠医学

背景情况:

睡眠呼吸障碍 (SDB) 和肺功能减弱对冠心病 (CHD) 发病率的协同效应尚不清楚.
各种肺功能指数对心脏病发病率的预测值需要进一步研究.

研究的目的:

调查SDB和肺功能对心脏病发病率的综合影响.
确定不同肺功能指数对心脏病的预测能力.

主要方法:

从睡眠心脏健康研究 (SHHS) 中对3749名参与者的回顾性分析.
参与者根据呼吸暂停-低呼吸指数 (AHI) 分类为SDB和非SDB子组.
考克斯回归和ROC分析用于评估肺功能和心脏病相关性和预测价值.

主要成果:

在没有SDB的参与者中,观察到肺功能下降和心脏病风险增加之间的显著关联.
这种关联在SDB的参与者中是无意义的,这表明该组肺功能预测值有所降低.
肺功能对心脏病风险的增量预测性贡献随着SDB严重程度的增加而减少.

结论:

在没有SDB的个体中,肺功能是CHD的更重要的预测因素.
临床关注肺功能以减少心脏病风险,应优先考虑没有SDB的个体.
针对肺部健康的干预措施对于在特定人群中预防心血管疾病至关重要.

关键词:

呼吸暂停呼吸暂停指数冠心病是一种冠心病.肺功能肺功能肺功能睡眠呼吸障碍睡眠呼吸障碍睡眠呼吸障碍

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