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SARS-CoV-2感染降低了精子质量参数:对93名患者进行了前性一年后续研究

Christophe Depuydt¹, Eugene Bosmans², Jef Jonckheere³

¹Department of Hormonology and Reproductive Health, Algemeen Medisch Laboratorium (AML), Sonic Healthcare, Antwerp, Belgium; Department of Clinical and Molecular Pathology, AML, Sonic Healthcare, Antwerp, Belgium.

|June 12, 2023

概括

SARS-CoV-2 感染暂时影响精子质量,影响运动性,形态和 DNA 完整性. 虽然大多数参数在感染后恢复,但像抗精子抗体这样的免疫反应会影响恢复率和生育潜力.

科学领域:

生殖医学生殖医学
病毒学病毒学
免疫学免疫学免疫学

背景情况:

关于SARS-CoV-2对精子质量和生育能力的影响的纵向数据有限.
了解COVID-19对男性生殖健康的影响至关重要.

研究的目的:

分析SARS-CoV-2感染对各种精液质量参数的差异性影响.
为了调查COVID-19对精子参数和生育结果随着时间的推移的影响.

主要方法:

使用世卫组织标准评估精子质量的纵向观察队列研究.
精子DNA碎片化指数 (DFI) 和高密度稳定性 (HDS) 的量化.
通过光显微镜评估IgA和IgG抗精子抗体 (ASA).

主要成果:

SARS-CoV-2 感染影响了与精子生成周期 (流动性,形态, DFI, HDS) 独立的精子参数和依赖的参数 (精子度).
根据COVID-19后IgA和IgG-ASA的出现序列,患者被分组.
渐进性运动性根据ASA的存在而异,在没有ASA的患者中最低,在具有IgA和IgG-ASA的患者中最高.

结论:

感染SARS-CoV-2会在不同程度上改变精子参数,恢复受到个体免疫反应的影响.
机制包括免疫介导的半转化停止和免疫诱导的精子DNA损伤,这两种通常都是暂时的.
大多数精液参数在感染后恢复到基线水平,这表明对生育能力有暂时的影响.

关键词:

抗精子抗体是一种抗体.在 COVID-19 疫情中,DNA碎片化指数 (DFI) 是一个指数.生育能力生育能力生育能力精子的DNA受损.精子染色质结构测定 (SCSA)

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