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可注射的冷大气等离子激活免疫治疗水凝,用于增强癌症治疗

Tianxu Fang¹, Xiaona Cao², Bingzheng Shen¹

¹Department of Biomedical Engineering, McGill University, Montreal, QC, H3G 0B1, Canada; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3G 0B1, Canada.

|June 12, 2023

概括

这项研究引入了一种新的水凝疗法,将冷大气等离子体 (CAP) 与免疫检查点阻塞 (ICB) 结合起来,以改善癌症治疗. 这种方法可以增强抗瘤免疫力,并减少副作用,从而改善患者的治疗结果.

科学领域:

生物医学工程生物医学工程
免疫治疗是一种免疫疗法.
材料科学材料科学材料科学

背景情况:

免疫检查点封锁 (ICB) 在癌症治疗中表现有前途,但面临着低反应率和毒性等挑战.
冷大气等离子体 (CAP) 诱导免疫细胞死亡,释放瘤抗原并启动免疫反应.
有效的输送和降低系统毒性对于结合CAP和ICB疗法至关重要.

研究的目的:

开发一种凝介导的组合疗法,以提高ICB的疗效.
评估CAP诱导免疫细胞死亡和增强抗瘤免疫力的能力.
通过注射水凝来评估CAP和ICB的安全性和有效性.

主要方法:

一种可注射的Pluronic水凝被用于内注射CAP和ICB.
评估了水凝能够保存CAP产生的反应性氧和物种 (ROS/RNS) 的能力.
分析了诱导癌症免疫细胞死亡和随后的免疫反应.

主要成果:

普鲁罗尼克水凝有效地保护了CAP的长寿命ROS和RNS.
水凝介导的CAP治疗成功诱导了注射后的癌症免疫细胞死亡.
组合疗法显示出协同效应,增强了先天性和适应性抗瘤免疫力.

结论:

通过水凝介导的CAP和ICB组合为癌症治疗提供了一个有前途的策略.
这种局部化的方法可以引起强大的局部和全身抗瘤免疫反应.
该疗法显示出抑制瘤生长和预防转移性传播的潜力.

关键词:

癌症免疫疗法癌症免疫疗法寒冷的大气等离子体是什么?药物输送是药物输送的过程.免疫检查站封锁免疫检查站封锁可以注射的水凝.

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