在经外科化疗治疗的局部晚期胃癌中,免疫瘤微环境的动态分析
Irene Pecora1, Clara Ugolini2, Riccardo Giannini2
1Unit of Medical Oncology, Ospedale Misericordia, Azienda USL Toscana Sud Est, Grosseto, Italy.
Oncology
|June 12, 2023
概括
化疗 (FLOT) 在晚期胃癌 (GC) 中显著改变免疫瘤微环境 (TME). 瘤回归与特定的免疫细胞变化有关,这表明针对治疗反应量身定制的免疫特征.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- FLOT是一种用于局部晚期胃癌 (GC) 的标准外科化疗.
- 在GC中,FLOT对免疫瘤微环境 (TME) 的影响尚不清楚.
- 了解TME动态对于优化免疫疗法组合至关重要.
研究的目的:
- 为了研究在GC的FLOT处理过程中TME特征的变化.
- 为了将TME变化与治疗反应和临床病理结果相关联.
主要方法:
- 对25名GC患者的治疗前 (PRE) 和治疗后 (POST) 活检样本进行了前性分析.
- 免疫基因表达和免疫细胞概况的纳米链分析.
- TME变化与瘤衰退 (T回归) 的相关性.
主要成果:
- FLOT诱导了免疫基因表达的显著变化,包括细胞毒性和T细胞功能标记物.
- 瘤回归 (T回归) 与这些免疫修改有很强的关联.
- 患有T回归的患者在治疗后表现出T,CD8+T和B细胞的增加,以及瘤细胞的减少.
结论:
- 在局部发达的GC中,FLOT显著调节免疫TME.
- 瘤回归与独特的免疫细胞动态有关.
- 特定的免疫特征可以预测对基于FLOT的治疗的反应.
相关概念视频
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
01:27Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575