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Updated: Jul 26, 2025

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在周周血管空间 (DTI-ALPS) 进行扩散张力图像分析的跨供应商测试-重试验证,以评估淋巴系统功能

Xiaodan Liu^1,2,3, Giuseppe Barisano⁴, Xingfeng Shao¹

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.

Aging and disease

|June 12, 2023

概括

沿周血管空间 (DTI-ALPS) 的扩散张力图像分析方法可靠地评估淋巴系统功能. 这种经过验证的生物标志物在供应商,评级者和测试中显示出极好的可重复性.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
生物标志物开发生物标志物开发

背景情况:

淋巴系统 (GS) 从大脑中清除废物.
沿周血管空间的扩散张力图像分析 (DTI-ALPS) 是评估GS功能的一种拟议方法.
有限的研究已经验证了DTI-ALPS的可靠性和可重复性.

研究的目的:

验证DTI-ALPS方法的可靠性和可重复性,以评估淋巴系统功能.
建立ALPS指数作为GS评估的潜在体内生物标志物.

主要方法:

利用了MarkVCID联盟50名参与者的扩散张力成像 (DTI) 数据.
开发了两个处理管道,使用DSI工作室和FSL软件进行ALPS指数计算.
使用R工作室软件评估ALPS指数的交叉供应商,互评分器和测试-重新测试可靠性.

主要成果:

该ALPS指数显示了有利的扫描器间可重复性 (ICC=0.770.95,P<0.001).
观察到优异的评价者之间的可靠性 (ICC=0.961,P<0.001) 和测试重复性 (ICC=0.890.95,P<0.001).
ALPS指数被证明是GS功能的可靠指标.

结论:

使用ALPS指数的DTI-ALPS方法是评估淋巴系统功能的可靠和可重复的技术.
ALPS指数显示出强大的潜力,作为GS评估的验证体内生物标志物.
这项研究提供了强有力的证据,支持在临床和研究环境中使用DTI-ALPS.

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