快速眼动睡眠行为障碍与帕金森病之间的关系:肠道微生物群变化的指示
Pingchen Zhang1, Pei Huang1, Yuanyuan Li1
1Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Aging and disease
|June 12, 2023
概括
快速眼动睡眠行为障碍 (RBD) 与帕金森病 (PD) 共享肠道微生物变化. 特定的肠道细菌,如减少的Butyricicoccus和Faecalibacterium,可能标志着RBD进展到PD.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 快速眼动睡眠行为障碍 (RBD) 是帕金森病 (PD) 的一种前兆标志.
- 肠道功能障碍与PD有关,但其在RBD中的特定作用及其向PD的进展仍未得到充分研究.
- 调查RBD的肠道微生物变化对于了解PD的发病过程至关重要.
研究的目的:
- 探索RBD和PD之间一致的肠道微生物变化.
- 在RBD中识别特定的微生物生物标志物,这些生物标志物可以预测转化为PD的现象转化.
- 分析肠道微生物群与RBD中的临床症状之间的关系.
主要方法:
- 对肠道微生物组成的比较分析,包括异常性RBD (iRBD),具有RBD的PD,没有RBD的PD和正常的对照 (NC).
- 使用UniFrac指标的α和β多样性分析.
- 肠型分布和属级丰度概况.
- 微生物变化与RBD严重程度 (RBD-HK) 之间的相关性分析.
主要成果:
- 两组之间观察到β-多样性的显著差异,但在α-多样性中没有.
- 肠型分析显示,在NC中从细菌类占主导地位转向iRBD和PD组中的鲁米诺菌占主导地位.
- 与对照人群相比,七个细菌系显示了与RBD相关的iRBD和PD的一致变化.
- 在iRBD和带有RBD的PD中减少了Butyricicoccus和Faecalibacterium的丰度,与RBD严重程度降低相关,并将带有RBD的PD与没有RBD的PD区分开来.
结论:
- RBD表现出类似于PD的肠道微生物变化.
- 减少的Butyricicoccus和Faecalibacterium水平可能作为RBD转化为PD的潜在生物标志物.
- 肠道失生症是共享RBD和PD病理生理学的重要因素.
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