索马托斯塔丁信号调节过度饮酒行为通过杏仁体的中央核调节
Stacey L Robinson1, Todd E Thiele1
1Department of Psychology & Neuroscience, The University of North Carolina, Chapel Hill, NC, 27599, USA; Bowles Center for Alcohol Studies, The University of North Carolina, Chapel Hill, NC, 27599, USA.
Neuropharmacology
|June 12, 2023
概括
杏仁体中的索马托斯坦素 (SST) 影响过度饮酒. 这项研究表明,SST的使用减少了酒精摄入量,这表明它是治疗酒精使用障碍的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 成研究 研究成研究
背景情况:
- 索马托斯塔丁 (SST) 是一种神经,存在于调节情绪和行为的大脑区域.
- 酒精使用障碍 (AUD) 是一个重要的公共卫生问题,经常与神经精神疾病同时发生.
- 杏仁体 (CeA) 的中心核对酒精和焦虑行为至关重要,但SST在这里在酒精消费中的作用尚不清楚.
研究的目的:
- 调查CeA SST系统与过度饮用乙醇摄入之间的相互作用.
- 为了确定CeA中的SST是否影响过度饮酒的酒精消费.
- 探索SST受体2 (SST2R) 和SST受体4 (SST4R) 在调解这些效应中的参与.
主要方法:
- 在雄性和雌性C57BL / 6J小鼠中利用黑暗饮酒 (DID) 模型对狂饮乙醇摄入.
- 在三个DID周期后评估了CeA SST表达的变化.
- 将SST或SST受体激动剂直接注入CeA,以测量对乙醇消耗的影响.
主要成果:
- 像狂欢般的乙醇消费导致特别在CeA中减少SST表达,而不是底侧杏仁体.
- 直接将SST注入CeA显著减少了过度饮用乙醇的摄入量.
- 一个SST4R激动剂复制了SST的降酒效应,表明受体参与.
- 观察到的效应在雄性和雌性小鼠中一致.
结论:
- 过多的乙醇摄入改变了CeA内的SST表达.
- 在CeA内给予SST,可能通过SST4R,减轻了类似暴饮暴饮的酒精消费.
- CeA中的SST代表了管理酒精使用障碍的潜在治疗目标.
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