阿诺酸通过改善模式识别受体和2型糖尿病大鼠的正规Wnt通路激活来调节胰腺功能障碍
Khurram Aamir1, Gautam Sethi2, Mst Rejina Afrin3
1School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia; Akhtar Saeed College of Pharmacy, Canal Campus, Lahore, Pakistan.
Life sciences
|June 12, 2023
概括
阿诺酸 (AA) 通过调节Toll-like受体4 (TLR-4) 和Wnt信号通路来逆转2型糖尿病的胰腺损伤. 这表明AAAAAA.
科学领域:
- 代谢性疾病和内分泌学
- 分子生物学和信号通路.
- 自然产品化学和药理学
背景情况:
- 阿诺酸 (AA) 是一种具有已知的治疗作用的植物化学物质.
- 2型糖尿病 (T2DM) 与胰腺β细胞功能障碍有关.
- 在T2DM相关的胰岛素抵抗中,托尔类受体4 (TLR-4) 和Wnt信号之间的相互作用尚未完全理解.
研究的目的:
- 为了研究Arjunolic酸 (AA) 在2型糖尿病的小鼠模型中的治疗潜力.
- 阐明AA调节胰岛素信号传递的机制以及糖尿病胰腺中TLR-4和Wnt/β-catenin通路之间的交叉.
主要方法:
- 患有2型糖尿病的老鼠接受了不同剂量的阿诺酸 (AA) 治疗.
- 组织病理学分析 (马森三色,H&E染色) 评估了胰腺组织损伤.
- 分子分析包括自动化西式涂抹 (jess),免疫组织化学和RT-PCR来评估关键信号分子的蛋白质和mRNA表达.
主要成果:
- 阿诺酸 (AA) 治疗逆转了T2DM诱导的胰腺组织的亡和亡.
- AA降低了TLR-4,MyD88,NF-κB,p-JNK和Wnt/β-catenin的升高水平.
- 在糖尿病胰腺中,AA通过调节NF-κB和β-catenin交叉调节来提高IRS-1,PI3K和pAkt的调节.
结论:
- 阿诺酸 (AA) 显示出作为治疗T2DM相关的元炎症的治疗剂的潜力.
- 在T2DM中,AA有效调节参与胰岛素抵抗和胰腺功能障碍的关键信号通路.
- 需要进一步的长期临床前研究来确定AA在心脏代谢疾病中的临床相关性.
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