抗生素使用及其对早产新生儿食耐受性建立的影响
Neel K Singh1, Lester Will1, Sharef Al-Mulaabed2
1Department of Pediatrics, Division of Neonatology, Shands Children's Hospital, University of Florida, Gainesville, Florida.
American journal of perinatology
|June 12, 2023
概括
在早产婴儿早期使用抗生素并没有影响食耐受性. 需要进一步的研究来证实在接受抗生素的新生儿中这些发现.
科学领域:
- 新生儿重症监护室 (NICU) 的实践.
- 儿科胃肠病学 儿科胃肠病学
- 抗生素管理的管理.
背景情况:
- 抗生素在NICU中被广泛使用,通常用于没有确定的败血症的有症状的早产婴儿.
- 有关抗生素对新生儿肠道功能和微生物群的影响存在担忧.
- 之前对年龄较大的婴儿的研究表明,在暴露于抗生素后,可能会出现动力障碍和功能障碍.
研究的目的:
- 调查早期抗生素给药影响高风险早产婴儿肠道食耐受性的假设.
- 评估抗生素对新生儿食进步的影响.
主要方法:
- 进行了一项随机对照试验 (在症状早产新生儿中常规早期抗生素使用 - - REASON研究).
- 没有母亲感染风险因素的有症状的早产新生儿被随机分配到接受或不接受抗生素.
- 在两组中评估了食耐受性.
主要成果:
- 在接受抗生素和不接受抗生素的早产新生儿之间,没有观察到持续养耐受性的显著差异.
- 该研究发现,仅分析随机对照试验数据时,基于早期抗生素暴露的食问题没有差异.
结论:
- 根据这项研究,在早产婴儿早期服用抗生素并没有对食耐受性产生影响.
- 该研究强调了由于样本大小和临床交叉的局限性,强调了需要一个强大的前性随机研究.
- 需要进行进一步的研究,以确定早期抗生素使用与新生儿养结果之间的关系.
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