牙周病和口腔平细胞癌之间的关联:系统性审查和元分析
Rui Li1, Mengjie Hou1, Liying Yu1
1Department of Periodontology, School of Stomatology, China Medical University, Nanjing North Street 117, Shenyang, China.
The British journal of oral & maxillofacial surgery
|June 12, 2023
概括
牙周病 (PD) 与口腔状细胞癌 (OSCC) 的更高患病率有关. 然而,目前的证据并未证实PD与OSCC风险增加之间的因果关系.
科学领域:
- 口腔健康 口腔健康
- 在瘤学瘤学.
- 牙周病学 牙周病学
背景情况:
- 牙周病 (PD) 是一种慢性炎症状况,影响牙和支骨.
- 口腔状细胞癌 (OSCC) 是最常见的口腔癌类型.
- 由于共同的风险因素和炎症途径,PD和OSCC之间的潜在联系需要进行调查.
研究的目的:
- 系统地审查和对PD和OSCC之间的关联进行现有研究进行元分析.
- 评估患有PD的患者OSCC的患病率和风险.
- 在OSCC患者中评估PD的特定临床指标.
主要方法:
- 在多个数据库中系统地搜索文献,直到2022年8月.
- 包括来自970篇最初识别的论文中的13项研究.
- 使用几率比率 (OR),相对风险 (RR) 和95%置信区间 (95% CI) 的统计分析.
- 使用Begg和Egger测试评估的出版偏见.
主要成果:
- 在PD和OSCC患病率之间发现了积极的关联 (OR = 3.28).
- 严重的PD与OSCC患病率的相关性更强 (OR=4.23).
- 在患有PD的患者中没有观察到OSCC风险的显著增加 (RR = 1.50).
- 与对照人群相比,OSCC患者在膜骨损失,临床附着损失和探测时出血方面表现出显著差异.
结论:
- 牙周病与口腔状细胞癌的患病率之间存在积极的关联.
- 尽管存在这种关联,但目前的证据并未确定PD与OSCC风险增加之间的因果关系.
- 需要进一步的研究来阐明复杂的关系和潜在的因果机制.
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