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在有效的全身疗法时代,对转移性黑色素瘤进行转移切除术

Issac R Schwantes¹, Thomas Sutton¹, Shay Behrens¹

¹Department of Surgery, Oregon Health & Science University, Portland, OR, USA.

American journal of surgery

|June 12, 2023

概括

超慢性转移性黑色素瘤 (MMM) 患者从外科转移切除中受益,特别是当与有效的全身疗法 (EST) 结合时. 这种方法改善了整体存活率 (OS) 与早期治疗时期相比.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
黑色素瘤研究黑色素瘤研究

背景情况:

超慢性转移性黑色素瘤 (MMM) 提出了独特的治疗挑战.
有效的全身疗法 (EST) 已经推进了黑色素瘤治疗.
在MMM中外科转移切除术的生存益处仍在争论中.

研究的目的:

评估手术转移切除术对MMM患者的生存益处.
为了比较前后有效的全身疗法 (EST) 时代的结果.

主要方法:

从2009年到2021年,对226名MMM患者进行了回顾性分析.
根据转移切除和治疗时代 (前与后EST) 将患者分组.
从转移日期计算的总生存时间 (OS),使用卡普兰-梅尔分析.

主要成果:

总体存活率 (OS) 在后EST时代与前EST时代相比显著改善 (p < 0.001).
在后EST时代,转移切除与增加的OS相比没有切除有关 (p = 0.022).

结论:

转移切除术,特别是与EST结合时,在MMM患者中显示出生存益处.
这些发现支持了手术管理在当代黑色素瘤治疗范式中的持续作用.

关键词:

黑色素瘤是一种黑色素瘤.进行转移性切除术 (metastasectomy).发生转移的转移.系统性治疗是一种全身疗法.

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