两十年来骨折率的趋势 在结性脊柱炎的退伍军人中
Sali Merjanah1, Jean W Liew1, John Bihn2
1Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Arthritis care & research
|June 12, 2023
概括
随着时间的推移,结性脊柱炎 (AS) 患者的骨折风险增加,类似于一般人群. 瘤坏死因子抑制剂 (TNFi) 在AS患者中没有显著降低骨折率.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 骨健康 骨健康 骨健康
背景情况:
- 与一般人群相比,结性脊柱炎 (AS) 与骨折风险增加有关,可能是由系统性炎症驱动的.
- 瘤坏死因子抑制剂 (TNFi) 是一种可以通过减少炎症来减轻这种风险的药物.
研究的目的:
- 评估和比较AS个体中的骨折发病率与非AS匹配的比较者.
- 为了确定AS患者的骨折率在TNFi治疗开始后是否发生变化.
主要方法:
- 利用国家退伍军人事务数据库来识别AS患者和非AS比较者.
- 员工中断时间序列分析,以比较TNFi引入之前 (2000-2002) 和之后 (2004-2020) 的骨折率.
主要成果:
- 在2000年至2020年期间,AS患者的骨折发生率从每1000人年增加7.9至21.6
- 骨折率也在比较器上升,AS/比较器比率保持稳定.
- 在TNFi时代,与TNFi前时代相比,AS患者的骨折率没有显著下降.
结论:
- 骨折率在AS患者和一般人群中都显示出时间上的增加.
- 引入TNFi疗法并没有明显减少结性脊柱炎患者的骨折率.
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