在患有婴儿大肠的儿童中,肠道微生物组的组成和功能变异性
Samat Kozhakhmetov1, Zarina Meiirmanova2, Nurislam Mukhanbetzhanov3
1Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay batyr ave., Block S1, Nur-Sultan, Z05H0P9, Republic of Kazakhstan. skozhakhmetov@nu.edu.kz.
新生儿的婴儿结肠与明显的肠道微生物群发育有关. 特定的细菌群体和代谢途径在结肠病的婴儿和对照人群之间存在差异,这表明微生物组与结肠病的关系.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
背景情况:
- 婴儿,以无法安慰的哭泣为特征,引起了父母的焦虑.
- 以前的研究表明,肠道微生物群及其活动可能会导致导致结肠的不适.
研究的目的:
- 为了研究婴儿结肠和婴儿肠道微生物组的发展之间的关系.
- 为了比较有和没有的婴儿之间的微生物组结构和代谢途径.
主要方法:
- 对62名新生儿及其母亲进行前性观察研究.
- 从婴儿 (第1天至12个月) 和母亲收集便样本.
- 从婴儿和母亲的便样本的完整元基因组测序.
主要成果:
- 与对照组相比,患有的婴儿表现出不同的肠道微生物组轨迹.
- 的小组已经耗尽了Bifidobacterium,并丰富了Bacteroides Clostridiales,具有更高的微生物多样性.
- 代谢途径分析显示,结肠组的微生物群中糖解的丰富,与Bacteroides相关.
结论:
- 婴儿结肠绝对与婴儿肠道微生物组结构有关.
- 微生物组的变化,包括特定的种类和代谢途径,是婴儿大肠的特征.
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