植物灵感的粘合剂和可注射的天然水凝:体外和体外研究
Cristian Daniel Bohórquez-Moreno1, Kerim Emre Öksüz2, Emine Dinçer3
1Department of Metallurgical & Materials Engineering, Faculty of Engineering, Sivas Cumhuriyet University, 58140, Sivas, Turkey.
Biotechnology letters
|June 12, 2023
概括
药用植物水凝显示出作为传统治疗方法的安全,有效替代品的希望. 在酸盐 - 碳甲基纤维素水凝中的树提取物显示出抗菌活性和组织粘附性,在生物医学应用中具有低细胞毒性.
科学领域:
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
- 植物性疗法 植物性疗法
背景情况:
- 传统的治疗方法面临着诸如细菌耐药性和高成本等挑战.
- 药用植物为新疗法开发提供了潜力.
- 朱尼佩鲁斯 (Juniperus communis) L.因其治疗性质而受到研究.
研究的目的:
- 开发和描述含有Juniperus communis L. 提取物的水凝.
- 评估这些水凝的抗菌性,组织粘附性和细胞毒性概况.
- 评估生物医学应用中的水凝的体内安全性和有效性.
主要方法:
- 使用藻酸盐和碳甲基纤维素与树提取物配制的水凝.
- 对黄金葡萄球菌,大肠杆菌和杆菌的抗菌活性进行了测试.
- 使用L929细胞系 (IC50确定) 评估的细胞毒性.
- 在小鼠模型中进行了组织粘附和体内研究.
主要成果:
- 在100 mg/mL以上的度下,水凝表现出显著的抗菌活性.
- 观察到低细胞毒性与IC50值为17.32微克/毫升的提取物载荷的水凝.
- 在各种组织类型中表现出的高组织粘附能力.
- 在体内研究中没有显示出红斑或等不良影响.
结论:
- 基于的水凝显示出生物医学应用的潜力,因为它们的安全性和有效性.
- 开发的水凝为传统治疗提供了一个有希望的替代方案.
- 进一步的研究可以为特定的医疗保健用途优化这些水凝.
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