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由光或硫醇触发的生物活性酸的异构化

Zhiwei Zhang1,2, Giang N T Le1, Yang Ge3

  • 1Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.

Nature chemistry
|June 12, 2023
PubMed
概括

乙基候选药物可以在E和Z形式之间切换,改变它们的生物活性. 细胞中的谷氨酸催化这种异构化,使异构体的稳定性对药物疗效至关重要.

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