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Updated: Jul 26, 2025

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

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通过O-GlcNAcylation直接刺激de novo核酸合成

Lulu Chen1,2, Qi Zhou1,2, Pingfeng Zhang1

  • 1Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.

Nature chemical biology
|June 12, 2023
PubMed
概括

与O结合的N-乙糖胺 (O-GlcNAc) 直接控制核酸合成和NAD+的产生. 这种PRPS1的O-GlcNAcylation增强了它的活性,影响了癌症和艺术综合征等疾病.

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