在帕金森病中,静脉运动知觉是否与通过亚体内深脑刺激刺激的轴突通路相关?
Sinem Balta Beylergil1,2, Angela M Noecker1, Camilla Kilbane3,4
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Cerebellum (London, England)
|June 12, 2023
概括
帕金森病 (PD) 的深度大脑刺激 (DBS) 影响头部感知. 底核 (STN) 中的电极位置影响了结果,突出了基底-小脑网络的作用.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 垂体系统 垂体系统 垂体系统
背景情况:
- 感知线性运动 (标题) 对平衡和运动至关重要,但在帕金森病 (PD) 中受损.
- 针对PD患者的脑下核 (STN) 的深度大脑刺激 (DBS) 对前庭头部感知有不同的影响.
研究的目的:
- 确定大脑内的特定解剖连接,与经过STN DBS的PD患者的方向感知有所改善相关.
- 为了研究白质通道刺激在调节前庭方向感觉中的作用.
主要方法:
- 14名患有STN DBS的PD患者进行了标题歧视任务.
- 使用患者特定的DBS模型量化了与STN相邻的刺激白质通道的百分比.
- 相关性分析检查了受刺激的路径与标题歧视表现之间的关系.
主要成果:
- 改善向右方向的分辨能力与刺激对侧超直径,白色-亚thalamic和亚thalamic-pallidal通道正相关.
- 左STN白质连接的激活显著影响了向右方向的感知.
- 虽然有时会激活大脑 - 脑体投影,但它们的作用在所有参与者中并不一致.
结论:
- 这些发现强调了基底-小脑网络在STN-DBS调制前庭头部感知在PD中的重要参与.
- 特定的白质路径刺激,特别是超直接路径,对于改善这些患者的方向歧视至关重要.
相关概念视频
Parkinson's Disease: Overview
611
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
611
The Vestibular System
39.8K
The vestibular system is a set of inner ear structures that provide a sense of balance and spatial orientation. This system is comprised of structures within the labyrinth of the inner ear, including the cochlea and two otolith organs—the utricle and saccule. The labyrinth also contains three semicircular canals—superior, posterior, and horizontal—that are oriented on different planes.
39.8K
Parkinson's Disease: Treatment
303
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
303
Neural Regulation
39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
Major Somatic Sensory Pathways
1.1K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.1K
Equilibrium and Balance
4.8K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
4.8K


