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第三天的胚胎状态对单个胚胎细胞转移周期的生殖结果有影响吗? 一个队列研究研究
Jiaxin Qiu1, Tong Du1, Haiyan Guo1
1Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
概括
培养质量差的第3天胚胎到囊胚阶段可以获得良好的结果. 从具有更多细胞的第3天胚胎中选择芽细胞可以减少在生育治疗中流产的风险.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精过程中受精.
背景情况:
- 第三天 (D3) 胚胎质量是辅助生殖技术的一个关键因素.
- D3胚胎状态对胚胎细胞移植结果的影响需要进一步澄清.
研究的目的:
- 为了确定第3天胚胎状态是否会影响胚胎转移周期中的生殖结果.
- 评估D3胚胎分类与怀孕成功之间的关联.
主要方法:
- 追溯性队列研究涉及6906个玻璃化解的单个胚胎细胞转移周期.
- 用通用估计方程回归模型来分析胚胎状态和怀孕结果.
- 评估的结果包括生化妊娠,流产和活产率.
主要成果:
- 来自低等级D3胚胎的高质量的胚芽细胞显示出与高等级D3胚胎 (43.2%) 的活产率 (40.0%) 相当的活产率.
- 使用来自D3胚胎的胚芽细胞的周期少于五个细胞有明显更高的流产率 (9.2%) 与八个细胞 (7.6%) 相比.
结论:
- 质量差的D3胚胎可以成功培养到囊胚阶段,从而产生可接受的妊娠结果.
- 从8个或更多细胞的D3胚胎中选择芽细胞可能会降低早期流产的风险,当芽细胞质量相似时.
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