特里普托利德通过抑制ODC1减轻易怒肠综合征
Ning Zhu1, Liuyan Zhu2, Xueliang Zhang2
1Department of Cardiology, The Third Affiliated Hospital of Shanghai University (Wenzhou People's Hospital), The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, No. 299 Guan Road, Wenzhou, 325000, Zhejiang Province, People's Republic of China. zhuningccc@126.com.
BMC gastroenterology
|June 12, 2023
概括
来自Tripterygium wilfordii Hook F的Triptolide可以通过减少炎症和Ornithine Decarboxylase-1 (ODC1) 表达来治疗易怒肠综合征 (IBS),尽管它缺乏抗抑郁作用.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 刺激性肠综合征 (IBS) 是一种慢性肠脑轴障碍,影响患者的福祉.
- 三柳 (Tripterygium wilfordii Hook F,TwHF) 含有三化物,是一种具有抗炎性质的化合物.
- ptolide 在传统医学中用于治疗炎症疾病.
研究的目的:
- 在IBS的小鼠模型中研究托利德的治疗潜力.
- 为了评估三胺对IBS相关症状和肠道炎症的影响.
- 探索奥尼丁脱碳酶-1 (ODC1) 在三胺对IBS的疗效中的作用.
主要方法:
- 通过使用慢性急性联合压力 (CAS) 建立了IBS大鼠模型.
- 给模型大鼠服用了托利德,并评估了行为和生理参数.
- 皮质和结肠组织分析了病理变化,炎症细胞因子和ODC1表达.
主要成果:
- 在CAS诱导的IBS模型中,triptolide没有表现出抗抑郁或抗焦虑作用.
- 特里普托利德显著降低了便重量和腹部戒断反应得分.
- 特里普托利德降低了IL-1,IL-6和TNF-α的水平,并减少了大肠和大肠中的ODC1表达.
结论:
- 在由CAS诱导的IBS大鼠模型中,托利德证明了治疗效果.
- 在IBS中托利德的有益作用可能归因于减少ODC1.
- 这项研究强调了三胺作为IBS的潜在治疗方法,特别是在其抗炎作用方面.
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