透析酸盐降低率对维持血液透析患者死亡率的影响:一项匹配的病例控制研究
Shuixiu Yang1,2, Zongli Diao1, Wenhu Liu3
1Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
BMC nephrology
|June 12, 2023
概括
透析酸减少率 (PRR) 并没有显著影响维持血液透析 (MHD) 患者的死亡率. 这项研究没有发现PRR水平与MHD患者全因或心脑血管死亡率之间的联系.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床医学 临床医学
- 透析研究 透析研究
背景情况:
- 酸盐是透析过程中清除的小分子,类似于尿素.
- 透析酸盐减少率 (PRR) 反映了酸盐清除效率.
- 关于PRR与维持血液透析 (MHD) 患者的死亡率之间的关联存在有限的研究.
研究的目的:
- 调查透析PRR与MHD患者的临床结果之间的关联.
- 为了确定PRR水平是否与所有原因和心脑血管死亡率相关.
主要方法:
- 采用了追溯,匹配的病例控制研究设计.
- 数据来源于北京血液透析质量控制和改进中心.
- 根据PRR四分位数,患者被分为四组,并根据年龄,性别和糖尿病进行匹配.
主要成果:
- 分析包括4063名患者,其中2172名匹配患者 (每组543) 用于病例控制分析.
- 在PRR四分位数中,全因死亡率从19.3%到22.5%不等.
- 卡普兰-梅尔曲线和多变量考克斯回归显示,两组之间全因或心脑血管死亡率没有显著差异.
结论:
- 透析PRR与MHD患者的全因死亡没有显著的关联.
- 在透析PRR和心脑血管死亡之间没有发现显著的关联.
- PRR可能不是MHD患者死亡率的可靠预测指标.
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