Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Sequence Networks of Rotating Machines01:24

Sequence Networks of Rotating Machines

126
A Y-connected synchronous generator, grounded through a neutral impedance, is designed to produce balanced internal phase voltages with only positive-sequence components. The generator's sequence networks include a source voltage that is exclusively in the positive-sequence network. The sequence components of line-to-ground voltages at the generator terminals illustrate this configuration.
Zero-sequence current induces a voltage drop across the generator's neutral impedance and other...
126
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

11.3K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
11.3K
Per-Unit Sequence Models01:26

Per-Unit Sequence Models

99
An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
99
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.0K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.0K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.2K
Cyclic Processes And Isolated Systems01:19

Cyclic Processes And Isolated Systems

2.8K
A thermodynamic system with zero heat exchange and work is an isolated system. For these systems, the internal energy remains constant.
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state. 
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
2.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Safety and efficacy of inhaled IBIO123 for mild-to-moderate COVID-19: a randomised, double-blind, dose-ascending, placebo-controlled, phase 1/2 trial.

The Lancet. Infectious diseases·2023
Same author

LS<sup>X</sup>: automated reduction of gene-specific lineage evolutionary rate heterogeneity for multi-gene phylogeny inference.

BMC bioinformatics·2019
Same author

Back to the roots: Reducing evolutionary rate heterogeneity among sequences gives support for the early morphological hypothesis of the root of Siluriformes (Teleostei: Ostariophysi).

Molecular phylogenetics and evolution·2018
Same author

Trunk dental tissue evolved independently from underlying dermal bony plates but is associated with surface bones in living odontode-bearing catfish.

Proceedings. Biological sciences·2017
Same author

Activation of the IL-1β/CXCL1/MMP-10 axis in chorioamnionitis induced by inactivated Group B Streptococcus.

Placenta·2016
Same author

LS³: A Method for Improving Phylogenomic Inferences When Evolutionary Rates Are Heterogeneous among Taxa.

Molecular biology and evolution·2016
Same journal

SNPio: a Python interface for population genomic data processing.

BMC bioinformatics·2026
Same journal

SpaHNR: a spatial domain identification method via sparse attention-based hierarchical node representation and multi-view contrastive learning.

BMC bioinformatics·2026
Same journal

OpenIMC: an open-source platform for analyzing single-cell and spatial proteomics by imaging mass cytometry.

BMC bioinformatics·2026
Same journal

NAP: an open source pipeline for cross-domain microbiome profiling using Nanopore sequencing-derived amplicon data.

BMC bioinformatics·2026
Same journal

SurvGME: an R package for survival analysis with graphical and measurement error models.

BMC bioinformatics·2026
Same journal

SimMapNet: a Bayesian framework for gene regulatory network inference using gene ontology similarities as external hint.

BMC bioinformatics·2026
查看所有相关文章

相关实验视频

Updated: Jul 26, 2025

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.4K

CastNet:一个系统级的序列演变模拟器.

Carlos J Rivera-Rivera1, Djordje Grbic2

  • 1University of Bristol, Life Sciences Building, 24 Tyndall Avenue, Bristol, BS8 1TG, UK. carlos.riverarivera@bristol.ac.uk.

BMC bioinformatics
|June 12, 2023
PubMed
概括
此摘要是机器生成的。

通过链接序列和调控变化,CastNet模拟了基因组进化,揭示了基因网络中的共同进化动态. 这种新模型为复杂的进化系统和分子进化提供了洞察力.

关键词:
共同进化的共同进化共同进化的网络.复杂的系统复杂的系统.这就是Evo-devo.演化模拟的演化模拟进化系统是进化的系统.基因监管网络是基因监管网络.

更多相关视频

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.2K
Automated Analysis of C. elegans Swim Behavior Using CeleST Software
08:47

Automated Analysis of C. elegans Swim Behavior Using CeleST Software

Published on: December 7, 2016

12.8K

相关实验视频

Last Updated: Jul 26, 2025

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.4K
Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.2K
Automated Analysis of C. elegans Swim Behavior Using CeleST Software
08:47

Automated Analysis of C. elegans Swim Behavior Using CeleST Software

Published on: December 7, 2016

12.8K

科学领域:

  • 基因组学就是基因组学.
  • 系统生物学 系统生物学
  • 进化生物学 进化生物学

背景情况:

  • 传统的DNA进化模拟器是共进化无神论的,并模拟单个序列.
  • 生物系统是多基因的,基因产物相互影响彼此的进化.
  • 模拟这些关键的共同进化动态对于比较基因组学至关重要.

研究的目的:

  • 开发一种新的基因组进化模拟器,CastNet,可以模拟共同发展的调控相互作用.
  • 在模拟框架中明确链接序列演变和监管网络演变.
  • 研究多基因系统中的共同进化动态.

主要方法:

  • CastNet将基因组建为具有不断发展的调节相互作用的基因集合.
  • 基因调节网络 (GRN) 的相互作用决定了表型 (基因表达特征) 和适应性.
  • 一个遗传算法通过用户定义的基因组来进化种群,将调控突变与序列突变联系起来.

主要成果:

  • 在GRN中,CastNet显示了GRN中活跃基因之间的共同进化信号.
  • 不属于网络的基因表现出中性进化.
  • 对调节输出的选择性压力反映在基因序列中,建立了序列和调节进化之间的联系.

结论:

  • 对于研究基因组进化和复杂的进化系统而言,CastNet是一个重要的进步.
  • 模拟器为研究分子进化提供了一个新的框架,重点是序列共进化.
  • 这种方法可以对共同进化的网络产生深刻的见解.