开发一个生物标志物小组来评估患有慢性四肢威胁性缺血症 (CLTI) 的糖尿病患者的心血管风险:一项前性研究
Elisabetta Nardella1, Federico Biscetti2,3, Maria Margherita Rando1
1Cardiovascular Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, Roma, 00168, Italy.
Cardiovascular diabetology
|June 12, 2023
概括
像IL-6和CRP这样的生物标志物在糖尿病患者的下肢再血管化后预测不良心脏和四肢事件,患有慢性四肢威胁性缺血症. 早期识别高风险患者可以改善结果.
科学领域:
- 血管外科 血管外科
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 生物标志物研究 生物标志物研究
背景情况:
- 患有慢性四肢威胁性缺血症 (CLTI) 的糖尿病患者通常需要下肢内血管再循环 (LER).
- 后LER并发症包括主要不良心脏事件 (MACE) 和主要不良肢体事件 (MALE).
- 细胞因子在动脉样硬化中发挥作用,这表明MACE和MALE风险的潜在生物标志物.
研究的目的:
- 研究糖尿病CLTI患者LER后的基线生物标志物水平和MACE/MALE之间的关系.
- 评估一组炎症生物标志物对LER后血管结果的预测价值.
- 为了确定生物标志物是否能比传统因素更好地预测风险.
主要方法:
- 一项前性非随机研究,涉及264名接受LER治疗的糖尿病CLTI患者.
- 测量了基线血清生物标志物水平 (IL-1,IL-6,CRP,TNF-α,HMGB-1,OPG,索尔蒂林,奥门丁-1).
- 在重血管化后的12个月内,对MACE和MALE发病率进行了跟踪.
主要成果:
- 升高的IL-1,IL-6,CRP,TNF-α,HMGB-1,OPG和Sortilin水平与MACE和MALE的增加有关.
- 低奥门丁-1水平与MACE和MALE相反相关.
- 生物标志物包括在内显著改善了事件事件的风险预测模型.
结论:
- 特定炎症生物标志物的基线水平预测了LER后糖尿病CLTI患者的不良血管结果.
- 这种生物标志物小组可以帮助识别患有MACE,MALE和手术失败风险较高的患者.
- 炎症状态评估可以指导临床管理,以预防LER后并发症.
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