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可吸入的CAR-T细胞衍生外体作为治疗肺癌的帕克利塔塞尔载体

Wei Zheng¹, Tianchuan Zhu², Lantian Tang¹

¹Center for Infection and Immunity, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, 519000, Guangdong, China.

Journal of translational medicine

|June 12, 2023

概括

携带帕克利塔塞尔 (PTX) 的工程外体向肺瘤,减少大小和毒性. 这种纳米纤维平台增强了非小细胞肺癌 (NSCLC) 的化疗.

科学领域:

纳米医学是一种纳米医学.
癌症治疗癌症治疗
免疫学免疫学免疫学

背景情况:

非小细胞肺癌 (NSCLC) 是一个重大的全球卫生挑战.
帕克利塔塞尔 (PTX) 是一种常见的化疗,但其全身毒性会导致多器官损伤.
需要有针对性的输送策略来提高PTX的疗效和减少副作用.

研究的目的:

开发一种基于外体的输送系统,用于在肺癌中向输送帕克利塔塞尔 (PTX).
在正型肺癌模型中评估PTX载荷的化学抗原受体外体 (PTX@CAR-Exos) 的疗效和毒性.

主要方法:

工程T细胞衍生的外体体表达着化抗原受体 (CAR-Exos) 向美索林 (MSLN).
封装PTX进入CAR-Exos (PTX@CAR-Exos) 进行吸入输送.
利用一个正确的肺癌小鼠模型来评估治疗效果.

主要成果:

吸入的PTX@CAR-Exos显示瘤积累,瘤大小减少和延长存活时间.
治疗显示最小的全身毒性.
PTX@CAR-Exos调节了瘤微环境,通过CD8+T细胞透逆转免疫抑制,并增加了IFN-γ和TNF-α水平.

结论:

工程外体提供了一个有前途的基于纳米纤维的平台,用于增强化疗.
这种策略可以提高药物的疗效,同时尽量减少肺癌治疗中的副作用.
该方法为肺癌治疗当前临床挑战提供了潜在的解决方案.

关键词:

在CART-T中,我们可以使用CAR-T.外基因组是外基因组的组成部分.吸入式吸入方式肺癌是一种肺癌.帕克利塔克塞尔 (Paclitaxel) 是一种药物.有针对性的交付目标.

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