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莫桑比克与孕产妇亚临床疟疾相关的产周死亡率增加

Nieves Jaén-Sánchez^1,2, Gloria González-Azpeitia^2,3, Cristina Carranza-Rodriguez^4,5

¹Infectious Diseases and Tropical Medicine Division, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain.

Malaria journal

|June 12, 2023

概括

孕妇的亚临床疟疾与产周死亡率的增加有关. 像PCR这样的分子方法可以检测这些无症状感染,有助于在特有地区更好的孕产妇和新生儿结局.

科学领域:

热带医学是一种热带医学.
传染病传染病传染病
公共卫生公共卫生

背景情况:

撒哈拉以南非洲地区的孕妇经常有无症状的Plasmodium falciparum疟疾.
微观疟疾很难用传统方法检测,需要PCR等分子技术.
关于亚临床疟疾对母亲和新生儿健康的影响的研究有限.

研究的目的:

分析孕妇中亚临床疟疾的患病率.
评估亚临床疟疾与母亲和新生儿不良结果之间的关联.

主要方法:

一项涉及232名莫桑比克孕妇的横截面研究.
半嵌套多重PCR用于检测胎盘和周围血液中的Plasmodium falciparum.
多变量回归控制了孕前/孕 (PE/E),艾滋病毒和其他因素.

主要成果:

17.2%的女性通过PCR检测阳性检测出Plasmodium falciparum.
亚临床疟疾与更高的周边死亡风险有显著的关联 (aOR:3.50 [1.11-10.97]).
孕前/孕后和艾滋病毒感染也与孕产妇和新生儿不良结果有关.

结论:

亚临床疟疾,PE/E和HIV与孕妇的不良孕产妇和新生儿结局有关.
分子方法是识别无症状疟疾感染的敏感工具.
无症状疟疾的早期检测可以减少周围产妇死亡率和寄生虫传播.

关键词:

艾滋病病毒艾滋病病毒艾滋病病毒莫桑比克莫桑比克的莫桑比克是一个国家.孕前炎症/孕后炎症的情况怀孕怀孕怀孕怀孕亚临床疟疾亚临床疟疾

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