糖尿病性黄斑对血清铁状况指标的影响
Sevim Ayça Seyyar1, Ecem Önder Tokuç2, Gizem Gürbostan Soysal3
1Ophthalmology Department, Gaziantep University Hospital, Gaziantep, Turkey.
Clinical & experimental optometry
|June 13, 2023
概括
糖尿病黄斑 (DME) 患者的血清费里水平较高,表明铁代谢发生变化. 监测铁状况可能有助于在糖尿病患者中诊断和管理DME.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 临床化学 临床化学
背景情况:
- 糖尿病黄斑 (DME) 病理生理学涉及复杂的亚临床炎症.
- 铁代谢指标与糖尿病视网膜病变和潜在的DME病变产生有关.
- 血清费里丁是铁储量的指标,也起到炎症标记的作用.
研究的目的:
- 研究血清铁代谢标志物在糖尿病黄斑 (DME) 病变发生过程中的作用.
主要方法:
- 从2019年1月到2020年1月,对157名患者进行了回顾性审查 (DME,没有的非增殖性糖尿病视网膜病变,没有视网膜病变).
- 收集的数据包括眼科检查,禁食血液检查和内科门诊检查.
- 实验室数据的比较,包括铁代谢标志物跨患者群体.
主要成果:
- 在两组之间观察到肌素,HDL,MCV,血清铁,费里丁,TIBC和转激素和的显著差异 (p<0.050).
- 患有DME的患者表现出明显更高的血清费里水平.
- 其他铁状况标志物在患有DME的患者中明显较低 (p<0.050).
结论:
- 血清铁状况指标可以在患有DME的糖尿病患者的例行随访中提供诊断和预后价值.
- 铁代谢的改变,特别是铁素的升高,与糖尿病斑点有关.
- 进一步研究铁代谢在DME中的作用是有必要的.
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