澳大利亚低于最佳的抗精神病药物使用和滥用模式:例行收集的数据能告诉我们什么?
Jonathan Brett1,2,3, Malcolm B Gillies1, Nicholas A Buckley3,4
1Medicines Intelligence in Health, School of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
British journal of clinical pharmacology
|June 13, 2023
概括
在澳大利亚,低于最佳的抗精神病药物的使用令人担忧. 这项研究确定了西和奥兰扎的使用和联合摄入的趋势,强调了监测处方模式的必要性.
科学领域:
- 药物监督 药物监督 药物监督
- 公共卫生 公共卫生
- 精神病学是一个精神病学.
背景情况:
- 越来越多的担忧存在于低于最佳的抗精神病药物使用带来的危害.
- 确定特定的人口群体和与这些危害相关的药物模式对于有针对性的干预至关重要.
研究的目的:
- 分析澳大利亚抗精神病药物使用和相关危害的基于人口的趋势.
- 识别具有可能导致不良结果的抗精神病药物使用模式的不同人口群体.
主要方法:
- 使用的澳大利亚制药福利计划数据 (2015-2020年),新州毒药信息中心数据 (2015-2020年) 和澳大利亚冠状病毒记录 (2005-2018年).
- 使用隐性类别分析来对抗精神病药物使用模式进行分类.
- 测量了抗精神病药物的流行,死亡和中毒的趋势.
主要成果:
- 奎蒂亚平和奥兰扎平显示使用率最高. 奎蒂阿平的使用和中毒事件增加,而奥兰扎平的使用减少,但中毒事件显著增加.
- 涉及奎平和奥兰扎宾的中毒和死亡经常与阿片类药物,二胺和普雷加巴林一起发生.
- 确定了六种不同的抗精神病药物使用模式,包括持续使用高剂量的镇静剂和偶尔使用止痛药.
结论:
- 持续的,可能低于最佳的抗精神病药物使用与严重的危害有关.
- 鉴定的使用模式需要加强监控,例如通过处方监控系统,以减轻风险.
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