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人类小肠质降解细菌及其对乳病的潜在影响

Sahabram Dewala¹, Rahul Bodkhe, Yogesh Nimonkar

¹National Centre for Cell Science, Pune, India.

Journal of biosciences

|June 13, 2023

概括

新的益生菌细菌菌株BreviBacterium casei NAB46和Staphylococcus arlettae R2AA77可以降解质,通过在它们到达小肠之前中和免疫毒性素来抵消乳房病 (CeD) 的潜在新疗法.

科学领域:

胃肠道学和微生物学
消化系统的免疫学

背景情况:

病 (Celiac disease,简称CeD) 是一种免疫系统疾病,在基因易受影响的个体中由质引发.
目前的管理依赖于严格的无质饮食 (GFD),这提出了坚持挑战和并发症.
需要新的治疗策略,在肠道暴露之前降解质免疫原成分.

研究的目的:

为了识别新的质降解细菌 (GDB) 从结核病一级亲属 (FDRs) 的十二指肠活检.
描述由这些GDB产生的谷蛋白酶,用于CeD的潜在治疗应用.

主要方法:

查GDB使用质合剂板技术.
细菌菌株的识别和表征,包括全基因组测序.
酶净化,活性测定,用抗素抗体进行西部斑分析,以及分子对接研究.

主要成果:

鉴定并描述了Brevibacterium casei NAB46和Staphylococcus arlettae R2AA77作为GDB. 这两种细菌.
在B. casei中发现了降解质的基内酶 (PEP) 和在S. arlettae.中发现了基内酶 (GEP).
证明PEP和GEP有效地化免疫毒性类,其中缩的酶具有显著更高的特异性活性.

结论:

布雷维细菌casei NAB46和Staphylococcus arlettae R2AA77具有强大的谷蛋白酶活动.
已识别的PEP和GEP酶中和了关键的免疫性质蛋白类表位.
这些GDB及其酶显示出作为一种新的食补充剂,用于控制腹腔疾病的前景.

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