在发作期间,前带带皮带岛网络的动态演变
Yujiao Yang1, Dong Chen2, Jing Wang1
1Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
CNS neuroscience & therapeutics
|June 13, 2023
概括
在发作期间,前带皮层 (ACC) 和前岛皮层 (AIC) 显示出增强的动态合和刺激性. 这种连接分析有助于确定发作发作区 (SOZ) 和信息流向.
科学领域:
- 神经科学是一个神经科学.
- 发病学 (Epileptology) 是一个专业的学科.
- 计算神经科学是一种神经科学.
背景情况:
- 已知前环状皮质 (ACC) 和前岛状皮质 (AIC) 在生理状态下共同激活.
- 在发作期间,ACC和AIC之间的动态相互作用和功能连接尚未得到充分理解.
- 了解这些相互作用对于在中定位发作区域 (SOZ) 至关重要.
研究的目的:
- 调查发作期间ACC和AIC之间的动态功能连接和合.
- 评估在发作期间大脑区域兴奋度的变化,特别是激发/抑制 (E:I) 比率.
- 为了确定连接性和刺激性模式是否可以识别SOZ和信息流动方向.
主要方法:
- 分析了20名患者的立体电脑图 (SEEG) 数据.
- 在发作时的窄带振荡和非周期组件被参数化.
- 频率特定的非线性相关性分析评估了功能连接;无周期性斜率评估了E:I比率.
主要成果:
- 在发作开始时,ACC和AIC之间的功能连接 (相关系数h2) 与间/前期间相比显著增加.
- 在发作开始时,方向指数 (D) 显著增加,准确地指示信息流向 (准确率高达90%).
- 在发作开始时,E:I比率显著增加,SOZ地区的增长比非SOZ地区更明显.
结论:
- 在发作期间,ACC和AIC表现出动态合,在发作开始时功能连接性和兴奋性增加.
- 对连接性和刺激性模式的分析可以有效地识别ACC和AIC内的SOZ.
- 方向指数 (D) 可靠地表明了从SOZ到非SOZ区域的信息流,突出显示了SOZ中变化的刺激性.
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