在中风不同阶段的患者肠道微生物群的变化
1Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
CNS neuroscience & therapeutics
|June 13, 2023
概括
肠道失调症在中风后持续存在,随着恢复逐渐改善. 肠道微生物群的变化与认知功能相关,并可能影响中风预后.
科学领域:
- 微生物组研究的研究.
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 在中风后,急性观察到肠道失调,可能会影响结果.
- 在中风恢复期间肠道微生物群的纵向变化尚未得到充分理解.
研究的目的:
- 为了研究中风后肠道微生物群变化的时间特征.
- 探索肠道微生物群组成和中风恢复之间的关系.
主要方法:
- 在中风患者 (次急性和康复阶段) 和健康对照者之间比较肠道微生物群.
- 利用16S rRNA基因测序进行微生物社区分析.
- 与临床数据相关的肠道微生物群概况,包括迷你精神状态检查 (MMSE) 评分.
主要成果:
- 与对照组相比,中风患者的肠道微生物丰富度发生了变化,在亚急性和康复阶段有明显的模式.
- 在中风患者中,乳酸菌种的丰富性增加,而Butyricimona,Peptostreptococaceae和Romboutsia的丰富性减少.
- 在两个患者阶段,MMSE得分与肠道微生物群组成的相关性最强.
结论:
- 肠道失调症在亚急性和康复性中风阶段持续存在,随着康复逐渐改善.
- 肠道微生物群可能会通过BMI和相关因素影响中风预后.
- 肠道微生物群和中风后的认知功能之间存在显著的相关性.
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