氧化平衡得分和神经细胞相关的先天性异常
Suzan L Carmichael1,2, Wei Yang1, Chen Ma1
1Division of Neonatology and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Birth defects research
|June 13, 2023
概括
较高的氧化平衡得分,表明氧化应激较低,与某些先天缺陷的风险降低有关,如裂唇和四肢缺陷. 然而,观察到无脑症的几率增加,这表明氧化应激会影响神经发展.
科学领域:
- 生殖生物学 生殖生物学
- 发展性毒理学 发展性毒理学
- 营养科学 营养科学
背景情况:
- 氧化应激和氧化还原失衡会对胚胎发育产生负面影响.
- 先天性异常代表着一个重要的全球健康问题.
- 了解导致因素对于预防策略至关重要.
研究的目的:
- 调查氧化平衡得分与特定先天性异常风险之间的关联.
- 评估饮食和非饮食因素对氧化平衡的影响.
- 探索氧化应激在神经细胞发育缺陷中的作用.
主要方法:
- 发展两个氧化平衡评分 (OBS):饮食OBS和整体OBS.
- 在整体OBS中包含13种饮食营养素和8种非饮食因素 (例如吸烟).
- 利用国家出生缺陷预防研究数据的逻辑回归来分析赔率比率.
主要成果:
- 较高的整体OBS与口唇裂或口腔裂 (aOR 0.72) 和四肢缺陷 (纵向aOR 0.73,横向aOR 0.74) 的几率降低有关.
- 观察到无脑症的几率增加 (aOR1.40),整体OBS.较高.
- 饮食OBS产生了类似的结果;与状心脏缺陷的关联在很大程度上是无意义的.
结论:
- 氧化应激似乎有助于先天性异常,特别是与神经细胞发育相关的异常.
- 氧化平衡得分可以作为评估与环境和饮食暴露相关风险的指标.
- 需要进一步的研究来阐明将氧化应激与特定出生缺陷联系在一起的机制.
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